BLOS and Type 2 Diabetes


Is BLOS the primary source of Oxidative Stress causing Type 2 Diabetes?

By Peter G. Stroot, Ph.D.

BLOS is the better Theory of Oxidative Stress that causes Type 2 Diabetes. The following figures provide information compares the Current Theory and BLOS Theory of Oxidative Stress as the cause of Type 2 Diabetes. In the Current Theory, elevated glucose levels are thought to generate high levels of ROS production due to inefficient metabolism. However, the studies that are used as the basis of the Current Theory leave out one important fact: the glucose must be transported across the blood vessel wall to the adjacent tissue in order to generate ROS in the adjacent tissue.

Type 2 Diabetes results in elevated blood sugar levels, which suggests that glucose transport from the blood to the adjacent tissue is being inhibited. In fact, elevated sugar levels in the blood results in sugar being excreted in the urine via the kidneys. It is difficult to imagine how the adjacent tissue is being overwhelmed by glucose, when the glucose is in the blood.

Now, people with Type 2 Diabetes do suffer from Oxidative Stress, which is indicated by low plasma sulfide levels. If the adjacent tissue isn't the primary cause of Oxidative Stress, then there must be a better candidate: BLOS. The figure below shows how BLOS is generated by a diet (Western) rich in Inorganic Sulfur (Red Arrow on the Left). ROS positive blood cells generate high levels of ROS in the blood, which inhibits the transport of glucose to adjacent tissue resulting in a buildup of blood sugar. If sulfide from the digestive system (large intestine) is not the underlying cause of the ROS response by the blood cells, then something else must be triggering this response. Is it possible that elevated blood sugar concentration is causing the ROS response in the blood cells? If the glucose transport is not inhibited by elevated ROS, then it doesn't make sense that the blood glucose level would be elevated in the first place to cause the ROS response. Furthermore, Type 2 Diabetics have elevated blood glucose levels for hours at a time (sometimes several times per day). This would mean that all of the blood cells in the body would be exposed to elevated glucose levels, which would trigger all of the blood cells to generate high levels of ROS. If all of your blood cells were triggered to generate ROS, then the plasma sulfide would be depleted resulting in death. Elevated blood sugar isn't a good candidate for the underlying cause of BLOS or Oxidative Stress in adjacent tissue.